Results matching “results” from Research in Psychosomatic Medicine

  Overall, physiological indices relevant to ANS were hypo-reactive to mental work stress and psychological tension indices were high in the FSS patients compared with healthy controls.  These findings suggest that FSS patients have hypo-functional stress responses, and could not cope with the stress properly, so felt higher subjective tension feelings.

  While these findings were results by averaging, the cluster analysis divided the FSS patients into two clusters by autonomic response to the stress: high-lability and low-lability group (the number of low-lability group was larger).  The mood scores were higher in the high-lability group than in the low-lability group.

  Moreover, heart rate variability, well known as an index of autonomic function, was reduced at the pre-stress resting period in FSS patients.  This finding suggests that both reduced autonomic lability in pre-stress period and attenuated autonomic response to stress exist, and both dysfunctions would interactively yield the maladaptive process.

  These tendencies were not depend upon diagnosis, suggesting the existence of common pathophysiology in FSS patients.

1. Kellner R.: Functional somatic symptoms and hypochondriasis. A survey of empirical studies. Arch Gen Psychiatry, 42, 821-33, 1985
2. Peveler R, Kilkenny L, Kinmonth AL.: Medically unexplained physical symptoms in primary care: a comparison of self-report screening questionnaires and clinical opinion. J Psychosom Res, 42, 245-52, 1997
3. Reid S, Wessely S, Crayford T, Hotopf M.: Frequent attenders with medically unexplained symptoms: service use and costs in secondary care. Br J Psychiatry, 180, 248 -53, 200
4. Wessely S, Nimnuan C, Sharpe M.: Functional somatic syndromes: one or many? Lancet, 354, 936 -9, 1999
5. Henningsen, P., Zipfel, S., Herzog, W.: Management of functional somatic syndromes. Lancet, 369, 946-55, 2007.
6. Barsky AJ, Borus JF.: Functional somatic syndromes. Ann Intern Med, 130, 910 -21, 1999
7. Lacey JI, Bateman DE, VanLehn R.: Autonomic response specificity. An experimental study. Psychosom Med, 15, 8 -21, 1953
8. Wenger MA, Clemens TL, Coleman MA, Cullen TD, Engel BT.: Autonomic response specificity. Psyshosom Med, 23, 185-93, 1961
9. Fink P, Toft T, Hansen MS, Ornbol E, Olesen F.: Symptoms and syndromes of bodily distress: an exploratory study of 978 internal medical, neurological, and primary care patients. Psychosom Med, 69(1), 30-9, 2007
10. Henningsen, P., Zimmermann, T., Sattel, H.: Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom Med, 65, 528-33, 2003
11. Kanbara, K., Fukunaga, M., Mutsuura, H. et al.: An exploratory study of subgrouping of patients with functional somatic syndrome based on the psychophysiological stress response: its relationship with moods and subjective variables. Psychosom Med, 69, 158-65, 2007
12. Kanbara, K., Mitani, Y., Fukunaga, M. et al.: Paradoxical results of psychophysiological stress profile in functional somatic syndrome: correlation between subjective tension score and objective stress response. Appl Psychophysiol Biofeedback, 29(4), 255-268, 2004
13. Nimnuan, C., Rabe-Hesketh, S., Wessely, S., Hotopf, M.: How many functional somatic syndromes?.J Psychosom Res, 51, 549-57, 2001
14. Robbins, J.M., Kirmayer, L.J., Hemami, S.: Latent variable models of functional somatic distress. J Nerv Ment Dis, Oct;185(10), 606-15, 1997
15. Kanbara, K., Mitani, Y., Fukunaga, M. et al.: Characteristics of psychophysiological stress responses in patients with psychosomatic disorders. Japanese Journal of Psychosomatic Medicine, 45, 685-695, 2005
16. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation, 93, 1043-65,1996.